Quick Biochemistry - Nucleic Acids (Section 10 - No. 38)
What mechanism could allow cancer cells to avoid the effects of amethopterin?
Developing ways to break down amethopterin
Increasing the number of copies of the dihydrofolate reductase gene
Altering the dihydrofolate reductase gene so that the enzyme is not inhibited by amethopterin
Creating alternative ways to produce thymidylate